milk thistle depression

Antidepressant and Anti-anxiety Effects of Milk Thistle Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. To provide you with the most relevant and helpful information, and understand which J Basic Clin Physiol Pharmacol. Summary Milk thistle may increase breast milk production in women who are lactating, though very little research has been done to confirm its effects. Our website services, content, and products are for informational purposes only. Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. Phytother Res. This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. Together, you can make shared, well-informed decisions. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Get the facts on milk thistle for the liver. Milk thistle is promoted as a dietary supplement for . And Selenium too. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. . 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Federal government websites often end in .gov or .mil. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Silymarin: not just another antioxidant. But even if youve figured out how to manage the symptoms and compulsions, the side effects of many FDA-approved OCD medications can introduce a wide swath of issues and side effects. 2. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Can You Get Milk Thistle Naturally From Foods? There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. information and will only use or disclose that information as set forth in our notice of Milk thistle may not be safe for everyone. Multiple Myeloma vs. Leukemia: What Are the Differences? Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. *These statements have not been evaluated by the Food and Drug Administration. Milk thistle can also be taken with cholesterol-lowering medications, like statins. Longe, J., ed. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Milk thistle is a safe supplement that shows potential as a complementary therapy for various conditions, including liver disease, cancer and diabetes. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. 2023 Jan 14;19:133-151. doi: 10.2147/NDT.S376380. Read our. Milk thistle (Silybum marianum) is said to have certain health benefits, including liver health, diabetes management, cancer treatment, and more. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. 2018;9:1903. doi:10.3389/fimmu.2018.01903, Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. 10 Supplements You Should Be Taking After Menopause However, there is no solid evidence that supports these claims. Why does zinc cause anxiety and depression for some people? Depression and anxiety are associated with increased risk of developing AD. 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. One study questioned the benefits of milk thistle for liver diseases. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. There are no other food sources of this herb. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Uses of Lavender: Everything You Need to Know, 11 Popular Natural Remedies for the Common Cold, Natural Remedies for Alcohol Use Disorder, The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. However, its currently unclear if it has the same beneficial effects in humans. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. 2016 Jul;41(7):1662-72. doi: 10.1007/s11064-016-1881-5. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. Milk Thistle (and liver cleansing) has two workings: it supports the liver and it lowers the inactive rT3 in favour of the active T3. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). Milk thistle may lower blood sugar levels in people with type 2 diabetes. eCollection 2022. What Are the Risks of Taking Milk Thistle? The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. The best doses of milk thistle have not been established for any condition it may be used to treat. . 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010, Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Duplication is encouraged. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. Follow all directions on the product label and package. Dosing of milk thistle ranged from 150 mg twice a day to 300 mg twice a day. It is possible to take too much, and liver toxicity has been observed in people with cancer taking silybin at very high doses (10 to 20 grams per day). The terms milk thistle and silymarin are often used interchangeably. Clipboard, Search History, and several other advanced features are temporarily unavailable. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Therefore, it may be best to avoid milk thistle during these life stages. Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. Milk thistle Uses, Side Effects & Warnings - Drugs.com Fried, M.; Navarro, V.; Afdhal, N. et al. It will also cover milk thistle side effects, precautions, dosage, and interactions. Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. MeSH Skip the missed dose if it is almost time for your next scheduled dose. . 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. You should not use this product if you are allergic to milk thistle or if you have: past or present cancer of the breast, uterus, or ovary; or. Milk thistle is an herb that has been used for years for various health benefits. A double-blind controlled study. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. . The active ingredients in milk thistle are a group of plant compounds collectively known as silymarin (1). ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Its herbal remedy is known as milk thistle extract. Anxiety; Autophagy; BDNF; Depression; Silibinin. Milk Thistle Treatment for Children and Adults with - PubMed Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Its also used to protect the liver against toxins like amatoxin, which is produced by the death cap mushroom and is deadly if ingested (7, 8). A double-blind controlled study. HHS Vulnerability Disclosure, Help Would you like email updates of new search results? This site needs JavaScript to work properly. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-B) pathway. One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). 2014;97 Suppl 11:S31-S40. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. IBM Micromedex. How Long Does It Take for Milk Thistle to Work? - LiverSupport.com People may also find it painful and worry about its effects on their appearance. Also known as Silybum marianum, milk thistle is a perennial herb native to many continents and countries across the globe, including Southern Europe, Southern Russia, Asia Minor, Northern Africa, and the Americas. It could interact with many drugs, including some that treat high cholesterol, infections, insomnia, and blood pressure. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. Milk thistle has a distinctive purple flower and spiky leaves, grows to about 200 cm in height, and is found throughout the world. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). CNS Neurosci Ther. Milk thistle. You may opt-out of email communications at any time by clicking on Huberman: "Anything that reduces 5-alpha reductase is going to reduce DHT & maintain or extend the growth phase, the anagen phase, of hair growth. government site. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Milk thistle extract has a high amount of silymarin (between 6580%) that has been concentrated from the milk thistle plant. The .gov means its official. Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Neurochem Res. 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride. Its regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer (1, 5, 6). MILK THISTLE - Uses, Side Effects, and More - WebMD What Is Complementary, Alternative, or Integrative Health? Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. If you take any medicines regularly, talk to your doctor before you start using milk thistle. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Tajmohammadi A, Razavi BM, Hosseinzadeh H. It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls. . Bookshelf Summary Initial test-tube and animal studies have shown that milk thistle has some promising characteristics that could make it useful for protecting brain function. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. ", National Center of Complementary and Alternative Medicine (NCCAM): "Milk Thistle," Herbs at a Glance: Milk thistle., Medicinenet.com: "Generic Name: Milk Thistle Oral.". 2016;5147468. doi:10.1155/2016/5147468. Phytomedicine. Milk Thistle Can Help Fight Symptoms of OCD - Natural Wellness Update This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Well go over the methods that doctors use to determine this and provide a chart, Blessed thistle is an herb with a long history of use for digestive issues and breastfeeding. 1982;17:51721. 2023 Natural Wellness. Advanced Milk Thistle, 120 softgels - Life Extension Epub 2016 Mar 9. However, this is the only clinical study available. https://www.wolterskluwercdi.com/facts-comparisons-online/. Do not use this product without medical advice if you are breast-feeding a baby. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Acne is a chronic inflammatory skin condition. #1: Milk thistle detoxifies the liver. Click here for an email preview. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Exercise caution and start slow. Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Milk thistle seems to have few side effects, even when taken for several years. Zargani M, Ramirez-Campillo R, Arabzadeh E. Pflugers Arch. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. JAMA. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). People with diabetes often have high cholesterol. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Milk Thistle: Benefits, Uses, Side Effects, and More Do not use more of this product than is recommended on the label. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). It may also make chemotherapy work more effectively against certain cancers and, in some circumstances, even destroy cancer cells (9, 29, 30, 31). In a mini Review on the Chemistry and Neuroprotective Effects of Silymarin, published in 2017, researchers went so far as to say that silymarin promotes the inhibition of the inflammatory response generated during neurodegeneration.. We encourage you to discuss any decisions about treatment or care with your health care provider. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago Milk thistle. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. Although more research is needed on how it works, milk thistle is thought to reduce damage to the liver caused by free radicals, which are produced when your liver metabolizes toxic substances. The Gale Encyclopedia of Alternative Medicine, second edition, 2004. In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). However, the results from studies have been mixed, and not all have found milk thistle extract to have a beneficial effect on liver disease. Comparing Natural Remedies for OCD to Standard OCD Treatment While more research into milk thistle, silymarin, and its effectiveness in treating OCD is definitely needed, there is a wealth of information supporting the other health benefits of milk thistle for a host of ailments: Liver Health It is believed that milk thistle and silymarin bolsters liver function by prohibiting toxic substances from binding to liver cells (6). For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. 2022 Nov 29;23(23):14968. doi: 10.3390/ijms232314968. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This article looks at the evidence to, Whats the life expectancy of someone with cirrhosis of the liver? Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. It is also unknown whether milk thistle is safe for children. Someone please correct me if I'm wrong. However, how it affects humans is currently unknown. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Benefits. Milk thistle is sometimes used to treat skin conditions including mild psoriasis. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Accessed Oct. 30, 2020. It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. There is not enough scientific data to say whether or not milk thistle can help liver problems. the unsubscribe link in the e-mail. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. Milk Thistle: Health Benefits, Safety Information, Dosage, and More - WebMD Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Milk thistle can trigger allergic reactions. Recent research has explored the use of milk thistle. Phytother Res. This article will explore the uses of milk thistle and research on its potential benefits. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. Milk thistle is often sold as an herbal supplement. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Trigonella foenum-graecum(fenugreek)also is used for this reason. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Large-scale, properly-designed studies are needed. Adv Ther. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut-Brain Axis. Also notable is the fact that, of the 40 subjects that completed this trial, none had any adverse events or side effects with milk thistle supplementation (7). Is There a Reason Your Milk Thistle Isn't Working? Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. Digestion and Depression . 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin. 2005 - 2023 WebMD LLC, an Internet Brands company. Bookmark the permalink. 7 Science-Based Benefits of Milk Thistle - Healthline The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Am J Gastroenterol. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.

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