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CFB: The way-too-early top 25 for 2021 Everything you need to know for the draft The Raiders opened the season with three of their first four games on the road. Read more. play. What to know for fantasy: Najee Harris averaged over 4.0 yards per carry for the first time this season last week, but he failed to record a reception in Pickett's NFL debut. UPDATE: I made seven changes to my final mock draft -- starting with the No. But this will be an emotional weekend at Lucas Oil Stadium for the Colts. Around The NFL Podcast Co-Host. Meanwhile, the Cowboys are tied for second in the league with 15 sacks and own the best pass rush win rate in the NFL (56.3%), according to ESPN Metrics powered by NFL Next Gen Stats. This is a matchup of the worst passing offense in the NFL (Jets, 131 yards per game) vs. the worst passing defense (324 yards per game). What to know for fantasy: Henry didn't catch a single pass in the first two weeks but has eight (for 91 yards) over the past two weeks. And regardless of whos at quarterback, Adam Thielen and Stefon Diggs need to spark the Vikings' aerial attack early while the running game gets in its groove with Latavius Murray taking the reins for an injured Dalvin Cook. Read more. What to know for fantasy: Through four weeks, there were 44 players with at least 25 carries. Week 5 NFL predictions: Game Postponed. NFL Power Rankings Week 5 bet now, bet later Week 5 spot bets Under 50.5 (-110) Combined, both teams have begun the season 3-5 O/U while the Bengals are riding a three-game Under. -- Brady Henderson. Betting nugget: Over the past 15 seasons, teams favored by at least seven points in international games are 7-0 ATS (6-0 ATS in London). Buffalo is at least a three-point underdog on the road, suggesting this could be a trap game for the Bills after big wins over Denver and Atlanta. They're now +1.5. -- Turron Davenport, Bold prediction: The Bills, who possess the NFL's fourth-best rushing attack in terms of yards per game, will run for at least 150 yards against a Titans defense that has given up a combined 146 rushing yards over its past two games. See Week 5 rankings. Read more. Bold prediction: With quarterback Sam Darnold (mono) sidelined for a third straight game, the Jets' epic struggles on offense will continue. Cardinals 30, Eagles 27 -- Tim McManus, It's hard to know what the Jaguars are going to get from QB Blake Bortles each week, and this week may be even more of a mystery because the Jaguars may be without WR Marqise Lee because of a rib injury. Dolphins 17, Titans 14 -- James Walker, The Chargers finished 1-3 on trips to the East Coast last season and are in the midst of a nine-game losing streak. Stat to know: Texans edge rusher Whitney Mercilus now has four straight games with a sack, tied for the longest active streak in the NFL with Clay Matthews and Shaquil Barrett. Colts 23, 49ers 20 -- Nick Wagoner, The last thing the Colts can do is overlook the 49ers. Cimini's pick: Eagles 27, Jets 9 What to know for fantasy: Christian McCaffrey has set the bar so high that three straight games with more than 100 scrimmage yards isn't enough to put him in the good graces of fantasy managers. The versatile back is now on pace for 115 catches this season. Theyll give up some yards and some plays. See Week 5 rankings. passing windows despite a smaller 5-foot-10, 204-pound frame. Another big day could be in store for Bosa here, and don't be surprised if he brings back the "flag plant" celebration he used against Mayfield in that previous meeting. It's all here to help get you ready for a loaded weekend of NFL football. This scheme has not changed and is bolstered on the back end by Eddie Jackson, who leads the NFC in interceptions with three in four games. -- Rob Demovsky, Bold prediction: Aaron Rodgers throws for 300-plus yards and at least three touchdowns. -- John Keim, Bold prediction: Titans quarterback Ryan Tannehill will finish with 300 passing yards in a win over the Commanders. Stat to know: Daniel Jones needs two passing touchdowns and 72 passing yards to have the most in each category by a Giants quarterback in his first three NFL starts since the 1970 merger. The Colts, meanwhile, are scoring on 40% of their possessions, 11th best. Stat to know: Trevor Lawrence struggles under pressure, having the largest drop-off of any QB in QBR (-76) compared to when he's not pressured. FPI prediction: GB, 86.9% (by an average of 13.5 points), Matchup must-reads: How Saquon Barkley and AJ Dillon became the 'Quad Kings' of the NFL Landon Collins, Giants finalizing deal, sources say Packers' Aaron Rodgers wanted longer London trip Rodgers: 'This way of winning, I don't think, is sustainable', What to know for NFL Week 5: Score picks, bold predictions, fantasy tips, key stats for all 15 games, Which NFL teams still have roster holes? Prediction: Cowboys 28, Giants 17. Stat to know: Jared Goff is tied for the lead in passing touchdowns with 11. Veteran WR Cole Beasley retires after 11 NFL seasons, What to watch for: Rookie quarterback Kenny Pickett is set to make his first career start against a Bills defense that is tied with the San Francisco 49ers for giving up the fewest yards per game (234.5). The Steelers' 2022 quarterback journey, and what happens next, What to watch for: The Patriots have given up 325 rushing yards on 51 carries (6.37 on average) over their past six quarters, while the Lions rank first in the NFL in average yards per rush (5.9) and sixth in total rushing yards per game (164). Read more. Betting nugget: San Francisco is 1-13-1 ATS and 6-9 outright in its past 15 games as a favorite (since Week 12 of 2014). QB Teddy Bridgewater is 2-0 lifetime against the Jets, who look to go over .500 for the first time since a 1-0 start in 2018. The Packers opened the season with a disastrous loss at New Orleans . The offense remains a question mark, however, and could be without starting left tackle Rees Odhiambo because of a chest injury. Welcome to 2023 NFL draft week. Pick NFL winners straight up or against the spread and compete to win more than $14,400 in prizes! Betting nugget: The past four times Jacksonville was a favorite, it lost the game outright, with three of those losses coming against Houston. It won't hold, though, as J.J. Watt & Co. make life miserable for the Falcons' offensive line. Read more. Matchup rating: 56.9 | Spread: SF -3.5 (46.5), What to watch for: The 49ers are missing left tackle Joe Staley and cornerback Ahkello Witherspoon, both of whom play positions opposite Cleveland's best players in defensive end Myles Garrett (and DE/LB Olivier Vernon, depending on alignment) and receiver Odell Beckham Jr. With backups in the lineup, can the Niners neutralize two of Cleveland's biggest stars? They're catching the Eagles' normally dominant offense at the right time, with left tackle Jordan Mailata (shoulder) and right guard Isaac Seumalo (ankle) dealing with injuries. These two teams played last year in similar circumstances, with the Titans leaving with the victory due to Mariota's four touchdowns and a stout running game. ET | ESPN -- Jenna Laine, Bold prediction: The Falcons, with no Cordarrelle Patterson and against a good run defense, will manage to once again top 150 rushing yards with Tyler Allgeier leading the way. The Vikings are banged up on offense but probably still good enough to squeak out a close victory. Betting nugget: Atlanta has failed to cover 13 straight games against AFC opponents (1-12 outright). Depth charts for every team ET Thursday after a few more conversations with people around the NFL. What to know for fantasy: Dallas' Amari Cooper is on pace for a career-high 84 catches and has scored four times in four games this season. But Browns RB Nick Chubb leads the NFL in rushing first downs and rushes of 10-plus yards. NFL: Notable Super Bowl betting trends Additionally, the Eagles are averaging a league-high 8.79 passing yards per play while the Cardinals are giving up 7.36, which ranks 25th in the league. Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs Patrick Mahomes says Andy Reid 'stole the show' in TV ad, 9:30 a.m. So this is a game the Chargers normally would lose, which is why Im picking them to win -- along with the fact that I believe the Giants will have trouble stopping the Bolts talented pass-rushing duo of Melvin Ingram and Joey Bosa. -- Kevin Seifert, Bold prediction: Kirk Cousins will have another three-interception day against the Bears' defense, akin to the last time the Vikings played against Matt Eberflus in Indianapolis, where Cousins recorded a 15.7 passer rating and three picks. Which QB will Colts take in Round 1? Given the Colts' struggles protecting the quarterback (they've allowed 14 sacks, tied for fifth most in the league) and the Niners' ability to take advantage of porous offensive lines (nine sacks total against Seattle and Arizona), this would seem to be the type of game the 49ers can win. -- Rich Cimini, Bold prediction: Bridgewater with throw for 300 yards and three touchdowns, including two to Tyreek Hill. Walder's pick: Rams 27, Cowboys 17 NE-WSH | BAL-PIT | OAK-CHI Betting nugget: All four Bills games have gone under the total this season. But let's put the bold in bold prediction. Moody's pick: Cowboys 23, Rams 20 Expect the Raiders' overachieving defense to make a play or two -- paging Khalil Mack and his four sacks -- to jump-start the offense, and all will be right in Silver and Blackdom for a week, at least. Read more. The Bucs also gave up an uncharacteristic 189 rushing yards in their 41-31 loss to the Kansas City Chiefs last week -- the most they've surrendered since 2018. -- Alaina Getzenberg, Bold prediction: Bills RB Devin Singletary will have his first 100-yard game of the season. Theres a ton of excitement in Chicago about Trubisky -- and rightfully so. This season, Cooks has zero 100-yard receiving games and has averaged just 53 yards per game. He is seeing the most targets per route run (32.4%) among wide receivers this season. Big Ben's 3-1 home-away touchdown ratio since 2015 looms large here, especially with Bell looking like his 2016 self and Jacksonville entering the week allowing 5.7 yards per carry, the league's worst by a large margin. This is the second-longest current home losing streak in the NFL behind the Cardinals, who have dropped seven in a row at home. ET games. Also note that the Redskins enter the game ranked 29th in rushing yards allowed per game (147.5). These teams are evenly matched, so quarterback play could make the difference. Read more. It all culminates with a Monday Night Football matchup between the Raiders and the Chiefs on ESPN. Read more. Watson will continue to play well, but the Texans defense will have a tough time containing the speed Kansas City has on offense. -- Adam Teicher, To celebrate 100 years of pro football, Peyton Manning travels the country to see the people and places that made the NFL the NFL. They have the NFL's second-ranked rushing defense, surrendering only 59.3 yards per game, and they held Christian McCaffrey to just 37 rushing yards in Week 2 (53 all-purpose yards) and the Rams to just 28 total rushing yards in Week 4. What to know for fantasy: Tony Pollard averaged 3.0 catches per game through two weeks, but in the past two weeks, he has a total of 2 receiving yards. At 0-4, the Browns talked a good game all week, but there was a feeling that folks were looking over their shoulder. Read more. -- Adam Teicher, Bold prediction: Raiders cornerback Amik Robertson will have a takeaway against the Chiefs. So it is possible things don't get better for Stafford this week. Sidney Jones (hamstring) has practiced this week in hopes of playing. -- Mike DiRocco, Bold prediction: Texans wideout Brandin Cooks will have his best outing of the season with a 100-yard game. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. His six catches last week against the Chargers are 60% of his grabs for the season. What to know for fantasy: Dalvin Cook has rushed for a touchdown in all four weeks this season and has seen his reception total increase each week as he continues to make a bid as a top-tier fantasy RB. -- Jordan Raanan, Bold prediction: Minnesota will bench Diggs in Week 5 to send a message to the star receiver, especially after he missed practice for non-football injury-related reasons earlier in the week. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. They're tied for fourth with 25 explosive pass plays (16-plus yards), and Miami's banged-up secondary is giving up huge chunks in the passing game (31st in yards). We answered the biggest post-draft question for all 32, LB Barrett's 2-year-old daughter drowns in pool, Deion 'ashamed' after only 1 HBCU player drafted, Sources: NFL eyes May 11 to release schedule, Teams set NFL record with 43 trades during draft, Jets coach Saleh: Rodgers making 'presence felt', Cowboys scout emotional as team drafts his son, Rams use 'Mr. What to know for fantasy: Derrick Henry has nine straight games with either over 100 total yards or a rushing touchdown. Cowboys D reaching elite levels of legendary Doomsday Defense? The Pats are coming off a 16-point performance in which quarterback Tom Brady completed just 18 of 39 passes for 150 yards and an interception. Here's how Week 5 is shaping up as we continue through the 2021 season CBSSports.com . The 2023 NFL Draft continues today in Kansas City! Read more. Herbert also totaled five touchdowns. Betting nugget: Bridgewater is 25-7 against the spread (ATS) in his career as a starting quarterback, the best mark by any QB with at least 15 starts in the Super Bowl era. Yes, he's 2-0, but the Saints will need more from Bridgewater, 1 p.m. With a banged-up Steelers defense that has struggled since T.J. Watt's Week 1 injury, this game has the potential for any number of Buffalo offensive superlatives. And the Dolphins' struggling offense presents three receivers who could give them fits once again. See Week 5 rankings. -- Rob Demovsky. FPI prediction: LAC, 65.1% (by an average of 5.4 points), Matchup must-reads: Broncos' 'world of suck' won't be easily fixed How Chargers kept team from splintering during Gordon holdout Chubb's injury further exposes Broncos' house of cards, 4:25 p.m. What to know for fantasy: After scoring 11 times in his first 14 games last season, Hopkins has scored just twice in his past seven games (playoffs included). Walder's pick: Seahawks 19, Saints 16 It prompted Packers coach Matt LaFleur to say this week that defensive coordinator Joe Barry needs to have his players "play more physical" and "in certain situations you might have to put an extra defender in the box." Chuck Pagano has never started a season 1-4 as coach of the Colts. Betting nugget: Philadelphia is 10-0 all time against New York and 9-1 ATS. Their offense is clicking on all cylinders, and their defense finally showed signs of life in the second half Sunday, holding Dallas to a mere six points. 3 all-time rusher Barry Sanders, 1 p.m. Betting nugget: Last season, first-round quarterbacks making their first career starts went 0-5 ATS. -- Mike Reiss. That was a reminder that their defense remains one of the NFL's best. FPI prediction: PHI, 75.9% (by an average of 9.7 points), Matchup must-reads: Jalen Ramsey to the Eagles: What are the realistic odds? The advantage for the Packers does not lie so much in the schematics, but the rest, which allowed four key offensive players more time to get ready. As Giants defensive coordinator Wink Martindale said of the Packers QB, 'It's like owning a python and saying, 'Don't worry about it, he won't bite.'" Read more. Gregg Rosenthal. The Bills and Steelers matchup, discussed in greater detail below, moved from Buffalo minus-8 to Buffalo minus-14, but a perhaps. Bengals quarterback Joe Burrow has excelled in his past eight road games, going 6-2 with 18 touchdowns and four interceptions. -- Jake Trotter, Bold prediction: The Chargers have yet to put together a 100-rushing yard performance this season, but that will change Sunday against the Browns. Chiefs 24, Texans 20 -- Adam Teicher, Deshaun Watson and the Texans' offense made a big statement scoring 57 points against the Titans. What to watch for: The Patriots have given up 325 rushing yards on 51 carries (6.37 on average) over their past six quarters . The Vikings' passing game has been bad (169.0 yards per game), prompting receiver Adam Thielen to express his frustrations and, in turn, Cousins to apologize. Atlanta has rushed for at least 179 yards in three of its four games. NYG-GB | ATL-TB | PIT-BUF This has the makings of another close loss. Listed at 5-foot-8, 187 pounds, he stood tall against Denver last week with a 68-yard scoop-and-score TD and played tough defense against Jerry Jeudy. What to know for fantasy: T.J. Hockenson had 24.2 fantasy points through three weeks before exploding for a career-best 39.9 points last week against the Seahawks. -- Katherine Terrell, Bold prediction: Ryan Neal will take over for Josh Jones in the starting lineup and spark Seattle's struggling defense with a game-changing takeaway. More: NFL Week 5 odds: Money lines, point spreads, over/under for every Week 5 NFL game. The answer is to be determined, Cruz expects Minshew will lead Jags over Allen's Panthers (1:17), Week 5 NFL game picks, schedule guide, fantasy football tips and more, Which NFL teams still have roster holes? What's more, it's Mayfield at quarterback for the Panthers this time, the same signal-caller Bosa made a point of terrorizing in 2019 with two sacks, a forced fumble and a fumble recovery. It's time to look ahead to Week 5. They'll do just enough to keep things that way. And the Chargers have allowed 5.4 yards per rush, the second worst in the NFL. Chalk home | NFL home | CFB home, Bold prediction: The Cardinals' passing game will finally lead them to a win. Stat to know: Allen has accounted for all 12 of the Bills' offensive touchdowns this season (either pass or scored). Jalen Ramsey to the Eagles: What are the realistic odds? What to know for fantasy: When you see "Brady vs. Atlanta," you likely think about the Super Bowl comeback, but that's not going to help you. With coaching staff in place, what's next for Carolina Panthers? Victor Cruz contends that Gardner Minshew is better equipped to lead his team to victory in the matchup with Panthers QB Kyle Allen. Stat to know: According to NFL Next Gen Stats data, Aaron Rodgers ranked first in completion percentage into tight windows in 2016. However, Miami is vastly improved in that area, allowing just 3.1 yards per rush and 78 yards per game this season. He is tied with Russell Wilson for the most in the NFL in that span. ET | CBS 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades. Betting nugget: Smith is 23-15 ATS in his career, including 10-2 ATS in his past 12 starts and 5-2 ATS with Seattle. What to know for fantasy: Since Week 15 of the 2017 season, just once has a player rushed for 90 yards against the Steelers in Pittsburgh. Bengals 14, Bills 10 -- Katherine Terrell, Coach Todd Bowles says "2-2 is nothing to brag about." Packers 33, Cowboys 27 -- Todd Archer, The Chiefs are 8-1 against quarterbacks in their first season as starters since Andy Reid arrived as head coach and Bob Sutton as defensive coordinator in 2013. He needs nine receptions on Sunday to break the five-game record, held by Zach Ertz (2018) and Eric Johnson (2004). Betting nugget: Washington has failed to cover in three straight games. Allgeier and Caleb Huntley will handle the majority of the work with Patterson (knee) on injured reserve, and the two young backs will alternate to cause problems for the Buccaneers. ET | Fox Matchup rating: 65.9 | Spread: KC -11 (56), What to watch for: The Chiefs' defense allows a touchdown or a field goal on an alarming 43% of their defensive possessions, 25th in the league. Keim's pick: Patriots 27, Redskins 7 We answered the biggest post-draft question for all 32, LB Barrett's 2-year-old daughter drowns in pool, Deion 'ashamed' after only 1 HBCU player drafted, Sources: NFL eyes May 11 to release schedule, Teams set NFL record with 43 trades during draft, Jets coach Saleh: Rodgers making 'presence felt', Cowboys scout emotional as team drafts his son, Rams use 'Mr. Plus, Antonio Brown is angry and wants the ball, which means he's due for a big game. Betting nugget: Since the start of last season, Dallas is 9-1 ATS on the road and 13-2 ATS in conference games. That's tied for the most outright wins without a loss in any matchup in NFL history, according to Elias Sports Bureau research. Facebook; Twitter; Facebook Messenger; Pinterest; Email; Scoring is up across the NFL. What to know for fantasy: Pittsburgh's Diontae Johnson owns a 20.5% target share this season from Rudolph, up from his 9.7% rate with Ben Roethlisberger under center. -- David Newton, Bold prediction: San Francisco 49ers defensive end Nick Bosa will have three sacks in his second career game against the Panthers. Paired with fellow receivers John Brown and Jaron Brown, the Arizona wideouts pose a threat to a vulnerable Eagles cornerback group. FPI prediction: TEN, 74.0% (by an average of 8.9 points), Matchup must-reads: Taylor Lewan's return could be a boon for Titans' offense Allen progressing but still in protocol Gore closing on No. See Week 5 rankings. Since the start of last season, 13 of the Bills' 20 games have gone under. Stat to know: Geno Smith has a 77.3 completion percentage this season, the highest by any QB through a team's first four games of a season in NFL history (min. Baby's pick: Cardinals 24, Bengals 21 FPI prediction: LA, 65.1% (by an average of 4.7 points), Matchup must-reads: Jerry Jones: An 'injustice' not to give coach McCarthy credit Police report filed in Wagner tackle Cowboys D reaching elite levels of legendary Doomsday Defense? Stat to know: The Niners' Jeff Wilson Jr. has scored multiple rushing touchdowns in two straight games. Tannehill had only two 300-yard passing games last season and has yet to have one this year. They'll be energized, while at home against a tough division rival, and will sneak out another close win. Since Chicago isnt a huge threat with its receivers, the defense will focus on Tarik Cohen and Jordan Howard in the running game. Matchup rating: 9.9 | Spread: CIN -3 (46.5), What to watch for: The game between winless teams could feature multiple sacks. Matchup rating: 42.0 | Spread: PHI -14.5 (43.5), What to watch for: The Eagles are paper-thin at cornerback after injuries to Ronald Darby and Avonte Maddox. With the return of Michael Gallup, Lamb will have chances to get away from Jalen Ramsey to make more plays. NFL best bets and picks for Week 5: Take the 49ers and the points, and the Jets-Falcons over. The Steelers have allowed three touchdowns on passes that have traveled at least 25 yards in the air, tied for third worst in the NFL. That would mean bigger roles for undrafted rookie Keelan Cole (four catches) and recently signed first-year player Max McCaffrey. Moody's pick: Chargers 27, Browns 20 In three games against the Packers, including playoffs, Elliott has run for 157, 125 and 116 yards on 79 carries. How drawing plays benefits McVay, others Markquese Bell capitalizing on Cowboys opportunity, What to watch for: The Ravens have lost a franchise-worst five straight home games (by a total of 12 points), dating back to last season. The Lions' defense gets another interception and Stafford throws for three touchdowns. However, Indianapolis figures to be rocking as Peyton Manning is honored with a statue, and mobile signal-callers like Jacoby Brissett have helped mitigate some of San Francisco's pass-rush ability. Matchup rating: 50.5 | Spread: BAL -3.5 (44), What to watch for: The Ravens' defense has a penchant for giving up big plays. Wagoner's pick: 49ers 27, Browns 24 But since 2017, his 29% completion rate ranks 38th out of 43 passers with at least 50 such attempts. Read more. The Commanders have allowed 1.17 yards after contact, also second best the past two weeks. This could be Rodgers' breakout game. (Game times are Sunday unless otherwise noted. Read more. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round . 1 wideout Jordan Matthews. See Week 5 rankings. ARI-CIN | DEN-LAC | GB-DAL Los Angeles Chargers at New Orleans Saints. Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. Stat to know: The Eagles are the only team to win the turnover battle in every game this season. Swift likely out again vs. Patriots, source says, What to watch for: The Vikings' defense has given up 1,054 passing yards this season, seventh-most in the NFL, as it meanders through the adjustment process to coordinator Ed Donatell's 3-4 scheme. Our NFL Nation reporters bring us the biggest keys to every game and a bold prediction for each matchup. Wells' pick: Chiefs 41, Colts 24 Matchup rating: 49.4 | Spread: LAC -6.5 (44.5), What to watch for: With Denver desperate for a win and fellow edge rusher Bradley Chubb done for the year because of an ACL injury, look for Von Miller to ignite the Broncos by getting after Philip Rivers, who has limited mobility. Walder's pick: Chargers 24, Browns 20 Betting nugget: Carolina is 3-15 ATS in its past 18 games. -- Jeff Dickerson, Biggest post-draft questions The role is great, but don't forget DeAndre Hopkins' suspension has just two weeks left on it. Injuries: Eagles | Steelers. The Bears, however, are the league's least-equipped team to exploit that shortcoming. Read more. NFL Week 5 picks, predictions: Colts vs. Broncos | Giants vs. Packers | Steelers vs. Bills Chargers vs. Browns | Texans vs. Jaguars | Bears vs. Vikings Lions vs. Patriots | Seahawks vs.. Unless, of course, two guys who never played with Mack in Oakland -- right tackle Trent Brown, whom the Raiders feted with a four-year, $66 million contract, and left tackle Kolton Miller, the Raiders' first-round pick a year ago -- have something to say about it and keep quarterback Derek Carr clean. FPI prediction: CIN, 56.2% (by an average of 2.2 points), Matchup must-reads: Cardinals WR Kirk likely out Sunday but ankle better Bengals put WR Ross on IR with shoulder injury, 4:05 p.m. (1:06). Peyton Manning is getting his own statue in front of the stadium and will have his jersey retired Sunday. However, Arizona's primary hope for winning this game lies with its run defense. ET | FOX Spread: NE -3.0 (45.5). See Week 5 rankings. If the Titans can't run, they are in trouble against the Dolphins, especially with the uncertainty of Mariota (hamstring). Expect the Texans to feed the Jaguars a heavy dose of Pierce, especially with run-game anchor Foley Fatukasi dealing with a quad injury. Finally, Seth Walder and Eric Moody give us final score picks for every game. The 2023 NFL draft wrapped up Saturday and through five rounds, 12 quarterbacks were selected -- the most in the common draft era. Meanwhile, Mahomes has thrown two interceptions, and the team has also lost two fumbles through four games. The last thing the Vikings need is for Diggs' situation to blow up into a full-blown distraction. Since Alex Smith got injured in Week 11 of last season, it has had an NFL-high five starting QBs. This should be a prime spot for them to get on track, even with the uncertainty surrounding receiver Stefon Diggs. Thursday night is going to be fun. ET | CBS Jump to a matchup: Wentz's seven picks are the most in the NFL. -- Paul Gutierrez. McManus's pick: Eagles 30, Jets 17 The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates . TB-NO | ATL-HOU | BUF-TEN -- DJ Bien-Aime. But the Commanders' run defense will be severely tested by Tennessee running back Derrick Henry. What to know for fantasy: Breece Hall has a touchdown or six catches in all four games this season and seems to be trending in the direction of a lineup lock. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round Conference Championship Super Bowl hidden HOU-JAX | SF-CAR | PHI-ARI Elliott is coming off the third-fewest rushing yards of his career, yet the Packers are allowing 142.3 yards per game and 5.0 yards per carry. The Chiefs' offense is a complete running and passing groove with Patrick Mahomes. No one really knows what to expect. They will welcome back Taylor Lewan from a four-game suspension with open arms. NFL SPREAD TO WIN TOTAL Philadelphia Eagles -5.5 -227 o49 Arizona Cardinals +5.5 +175 u49 49ers 37, Panthers 15 Point spread: 49ers (-6.5) cover by winning by more than 6.5 points. See Week 5 rankings. It's ranked fourth in rushing yards allowed per play (3.2), while the Eagles are ranked fifth in rushing yards gained per play (4.7). They also have a good secondary, which already has five interceptions. Even at full strength, Seattle's offensive line will have its hands full against a Rams front four that has given the Seahawks all sorts of trouble during the past few seasons. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round Conference Championship Super Bowl hidden

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